![]() This confounds the morphological source of the MR signal. Although targeted USPIO or MION agents bind endothelial cell surface markers, they also further extravasate into plaque, binding macrophages or other intraplaque constituents during the 24-hour wait. For background blood pool clearance, a typical delay of 24 hr is required between contrast treatment and imaging. Recent advanced techniques are emerging to visualize iron oxide particles as "hot spots" rather than signal dearth. Targeted iron oxide nanoparticles are easily detected with MR by their exaggerated signal dropout.
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